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Name: Seyed Mahmoud (Masiha) Hashemi

Ph.D. in Immunology

Assistant Professor at Shahid Beheshti University of Medical Sciences

M.C. NO: 3257

Date of Birth: 16.11.1356   / Sunday, February 5, 1978

Marital Status: married

Address: Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

P.O. Box: 

Fax: +98 21 22439970

Email1: smmhashemi@sbmu.ac.ir

2000-2002       B.Sc.:  Clinical laboratory science, Shaid Beheshti University, Tehran, Iran

2002-2005       M.Sc.: Immunology, Tarbiat Modares University, Tehran, Iran

2008-2012      Ph.D:  Immunology, Tarbiat Modares University, Tehran, Iran

1.      The winner of  17th Razi Research Festival on Medical Sciences, Tehran, IRAN, 2012.

2.      The second winner of  16th Razi Research Festival on Medical Sciences, Tehran, IRAN, 2011

2003-2006            Phase 1 human trial of  autologous bone marrow-hematopoietic stem cell transplantation in patients with decompensated  cirrhosis

2002-2006            Differentiation of human embryonic stem cells into hepatocytes in 2D and 3D culture systems in vitro

2002-2006            Comparison the Protective Effect of Mucosal BCG Vaccination with Subcutaneous Against Leishmania     Major Infection in Susceptible BALB/c Mice

2007-2009            Production of  hepatocytes  from stem cells

2007-2009            Production of  hepatocytes  from stem cells in 3-D culture systems

2007-2011            Establishment and differentiation of mouse  embryonic stem cell

2008-2011            Transplantation of bone marrow derived mesenchymal stem cells in diabetic mice

2009-2011           Transplantation of bone marrow derived mesenchymal stem cells in EAE mouse model mice

2009-2012           Establishment of mouse model of autoimmune disease

2009-2012           Immunomodulatory effects of mesenchymal stem cells in autoimmune diabetes

2009-2012           Immunomodulatory effects of mesenchymal stem cells in Mouse Model of Multiple Sclerosis

ü    Stem cell (in vitro and in vivo studies)

ü    Establishment of mouse model of autoimmune disease

ü    Establishment, Culture and differentiation of human and mouse embryonic stem cell

ü    Isolation, culture, expansion and differentiation of bone marrowadipose tissue,  and cord blood mesenchymal stem  cells and hematopoietic stem cells.

ü    3-D culture of stem cells

ü    Immunology Methods:

ü    Proliferation assay (MTT, LTT), DTH, Western blot, ELISA, Immunocytochemistry

ü    Production of monoclonal antibody

ü    Cellular and Molecular Biology Methods:

ü    Cell Culture (Macrophages, Spleenocytes and cell lines), Nitric oxide assay, Electrophoresis

ü    Care and handling of laboratory animals:

ü    Laboratory animal research–General maintenance, dissection, tissue isolation, primary cell isolation

1. Essential Cell Biology (2004), Author(s): Alberts B, Bray D, Johnson A, Lewis J, Raff M, Roberts K, Walter . Translator(s): Baharvand H, Sheikhian A Mirhabibi B, Farzaneh, Hashemi SM, Ebrahimi M, Zare N, Moradi Sh. Publisher(s):House of Biology (Tabesh-e Andisheh)

[1]         N. Abbasi, S. M. Hashemi, M. Salehi, H. Jahani, S. J. Mowla, M. Soleimani, and H. Hosseinkhani, “Influence of oriented nanofibrous PCL scaffolds on quantitative gene expression during neural differentiation of mouse embryonic stem cells.,” J. Biomed. Mater. Res. A, vol. 104, no. 1, pp. 155–64, Jan. 2016.

[2]         A. Ardeshirilajimi, F. Rafeie, A. Zandi-Karimi, G. A. Jaffarabadi, A. Mohammadi-Sangcheshmeh, R. Samiei, A. Toghdory, E. Seyedjafari, S. M. Hashemi, M. U. Cinar, and E. L. Gastal, “Fat harvesting site is an important determinant of proliferation and pluripotency of adipose-derived stem cells,” Biologicals, vol. 44, no. 1, pp. 12–18, Dec. 2016.

[3]         S. Dameshghi, A. Zavaran-Hosseini, S. Soudi, F. J. Shirazi, S. Nojehdehi, and S. M. Hashemi, “Mesenchymal stem cells alter macrophage immune responses to Leishmania major infection in both susceptible and resistance mice.,” Immunol. Lett., Dec. 2015.

[4]         H. Mohammadpour, A. A. Pourfathollah, M. Nikougoftar Zarif, and S. M. Hashemi, “Increasing proliferation of murine adipose tissue-derived mesenchymal stem cells by TNF-α plus IFN-γ,” Immunopharmacol. Immunotoxicol., vol. 3973, no. December, pp. 1–9, 2015.

[5]         M. Mondanizadeh, E. Arefian, G. Mosayebi, M. Saidijam, B. Khansarinejad, and S. M. Hashemi, “MicroRNA-124 Regulates Neuronal Differentiation of Mesenchymal Stem Cells by Targeting Sp1 mRNA,” J. Cell. Biochem., vol. 116, no. 6, pp. 943–953, 2015.

[6]         S. Oraee-Yazdani, M. Hafizi, a Atashi, F. Ashrafi, a-S. Seddighi, S. M. Hashemi, a Seddighi, M. Soleimani, and a Zali, “Co-transplantation of autologous bone marrow mesenchymal stem cells and Schwann cells through cerebral spinal fluid for the treatment of patients with chronic spinal cord injury: safety and possible outcome,” Spinal Cord, no. November 2014, pp. 1–8, 2015.

[7]         H. Rahavi, S. M. Hashemi, M. Soleimani, J. Mohammadi, and N. Tajik, “Adipose Tissue-Derived Mesenchymal Stem Cells Exert In Vitro Immunomodulatory and Beta Cell Protective Functions in Streptozotocin-Induced Diabetic Mice Model,” J. Diabetes Res., vol. 2015, pp. 1–10, 2015.

[8]         H. Rahavi, S. M. Hashemi, M. Soleimani, J. Mohammadi, and N. Tajik, “Assessing in vitro inhibitory effect of adipose-derived mesenchymal stem cells on C57BL/6 diabetic mouse splenocytes proliferation,” Razi J. Med. Sci., vol. 22, no. 132, pp. 95–106, 2015.

[9]         A. Mohammadzadeh, A. A. Pourfathollah, S. Shahrokhi, S. M. Hashemi, S. L. A. Moradi, and M. Soleimani, “Immunomodulatory effects of adipose-derived mesenchymal stem cells on the gene expression of major transcription factors of T cell subsets,” Int. Immunopharmacol., vol. 20, no. 2, pp. 316–321, 2014.

[10]       M. Naderi, H. Abdul Tehrani, M. Soleimani, I. Shabani, and S. M. Hashemi, “A Home-brew Real-time PCR Assay for Reliable Detection and Quantification of Mature miR-122.,” Appl. Immunohistochem. Mol. Morphol., vol. 00, no. 00, pp. 1–6, Dec. 2014.

[11]       I. Shabani, V. Haddadi-Asl, M. Soleimani, E. Seyedjafari, and S. M. Hashemi, “Ion-exchange polymer nanofibers for enhanced osteogenic differentiation of stem cells and ectopic bone formation.,” ACS Appl. Mater. Interfaces, vol. 6, no. 1, pp. 72–82, Jan. 2014.

[12]       M. T. Tahoori, A. A. Pourfathollah, M. Soleimani, E. Vasheghani-Farahani, A. Mohammadzadeh, A. Amari, S. M. Hashemi, and M. Mossahebi-Mohammadi, “Fibroblasts feeder niche and Flt3 Ligand as a novel inducer of plasmacytoid dendritic cells development in vitro.,” Int. Immunopharmacol., vol. 24, no. 2, pp. 474–480, Nov. 2014.

[13]       T. G. Ensie Sadat Mirsharif, Sakine Moaied Mohseni , Eisa Salehi, Seyed Mahmoud Hashemi, Mirsharif, M. Moaied, Salehi, Hashemi SM, and Ghazanfari, “Comparison of nitric oxide secretion by human adipose tissue-derived mesenchymal stem cells in healthy pregnant women and those with preeclampsia,” Daneshvar Med., vol. 20, no. 105, pp. 1–11, 2013.

[14]       S. M. Hashemi, Z. M. Hassan, A. A. Pourfathollah, S. Soudi, A. Shafiee, and M. Soleimani, “In vitro immunomodulatory properties of osteogenic and adipogenic differentiated mesenchymal stem cells isolated from three inbred mouse strains.,” Biotechnol. Lett., vol. 35, no. 1, pp. 135–42, Jan. 2013.

[15]       S. M. Hashemi, Z. M. Hassan, A. A. Pourfathollah, S. Soudi, A. Shafiee, and M. Soleimani, “Comparative immunomodulatory properties of adipose-derived mesenchymal stem cells conditioned media from BALB/c, C57BL/6, and DBA mouse strains.,” J. Cell. Biochem., vol. 114, no. 4, pp. 955–65, Apr. 2013.

[16]       G. T. Hosseinpur Z, Hashemi SM, Salehi E, “Mesenchymal Stem Cell Isolation from Adipose and Lung Tissues of BALB/c Murine and Comparison of Their Immunophenotype,” ZUMS Journal., 2013.

[17]       3 and Seyed Mahmoud Hashemi Sara Soudi, M.Sc., 1 Ahmad Zavaran-Hosseini, Ph.D., 1,* Zuhair Muhammad Hassan, Ph.D., 1 Masoud Soleimani, Ph.D., 2 Fatemeh Jamshidi Adegani, M.Sc., “Comparative Study of The Effect of LPS on The Function of BALB/c and C57BL/6 Peritoneal Macrophages,” cell J., vol. 15, no. 1, pp. 45–54, 2013.

[18]       S. O. Yazdani, M. Hafizi, a R. Zali, a Atashi, F. Ashrafi, a S. Seddighi, and M. Soleimani, “Safety and possible outcome assessment of autologous Schwann cell and bone marrow mesenchymal stromal cell co-transplantation for treatment of patients with chronic spinal cord injury,” Cytotherapy, vol. 15, no. 7, pp. 782–791, 2013.

[19]       F. Yousefi, M. Ebtekar, M. Soleimani, S. Soudi, and S. M. Hashemi, “Comparison of in vivo immunomodulatory effects of intravenous and intraperitoneal administration of adipose-tissue mesenchymal stem cells in experimental autoimmune encephalomyelitis (EAE),” Int. Immunopharmacol., vol. 17, no. 3, pp. 608–616, 2013.

[20]       E. Babaei, M. Sadeghizadeh, Z. M. Hassan, M. A. H. Feizi, F. Najafi, and S. M. Hashemi, “Dendrosomal curcumin significantly suppresses cancer cell proliferation in vitro and in vivo.,” Int. Immunopharmacol., vol. 12, no. 1, pp. 226–34, Jan. 2012.

[21]       A. Mohammadi-Sangcheshmeh, M. Soleimani, H. Deldar, M. Salehi, S. Soudi, S. M. Hashemi, K. Schellander, and M. Hoelker, “Prediction of oocyte developmental competence in ovine using glucose-6-phosphate dehydrogenase (G6PDH) activity determined at retrieval time.,” J. Assist. Reprod. Genet., vol. 29, no. 2, pp. 153–8, Feb. 2012.

[22]       S. O. Yazdani, M. Pedram, M. Hafizi, M. Kabiri, M. Soleimani, M.-M. Dehghan, I. Jahanzad, Y. Gheisari, and S. M. Hashemi, “A comparison between neurally induced bone marrow derived mesenchymal stem cells and olfactory ensheathing glial cells to repair spinal cord injuries in rat.,” Tissue Cell, vol. 44, no. 4, pp. 205–13, Aug. 2012.

[23]       and M. S. Azadeh OmidKhoda, Ahmad Gharehbaghian, Mostafa Jamali, Naser AhmadBeigi, Seyed Mahmoud Hashemi, Abas Rahimi, “Comparison of the prevalence of major transfusion-transmitted infections among Ira- nian blood donors using confidential unit exclusion in an Iranian population,” Hepat Mon, vol. 150, no. 43, pp. 2568–71, Oct. 2011.

[24]       A. Omidkhoda, A. Gharehbaghian, M. Jamali, N. Ahmadbeigi, S. M. Hashemi, A. Rahimi, and M. Soleimani, “Comparison of the prevalence of major transfusion-transmitted infections among Iranian blood donors using confidential unit exclusion in an Iranian population: Transfusion-transmitted infections among Iranian blood donors.,” Hepat. Mon., vol. 11, no. 1, pp. 11–3, Jan. 2011.

[25]       N. Pakravan, S. M. Hashemi, and Z. M. Hassan, “Adjuvant activity of GP96 C-terminal domain towards Her2/neu DNA vaccine is fusion direction-dependent.,” Cell Stress Chaperones, vol. 16, no. 1, pp. 41–8, Jan. 2011.

[26]       F. Yousefi, M. Ebtekar, M. Soleimani, and S. M. Hashemi, “Study of the Effects of Adipose-tissue Mesenchymal Stem Cells and Conditioned Medium on Cell Infiltration in the Brains of Experimental Autoimmune Encephalomyelitis C57 BL / 6 Mice,” modares J. Med., vol. 14, no. 4, pp. 75–88, 2011.

[27]       P. Dinarvand, S. M. Hashemi, and M. Soleimani, “Effect of transplantation of mesenchymal stem cells induced into early hepatic cells in streptozotocin-induced diabetic mice.,” Biol. Pharm. Bull., vol. 33, no. 7, pp. 1212–1217, 2010.

[28]       Z. Golzari, F. Shabkhiz, S. Soudi, M. R. Kordi, and S. M. Hashemi, “Combined exercise training reduces IFN-γ and IL-17 levels in the plasma and the supernatant of peripheral blood mononuclear cells in women with multiple sclerosis.,” Int. Immunopharmacol., vol. 10, no. 11, pp. 1415–9, Nov. 2010.

[29]       S. M. Hashemi, M. Soleimani, S. S. Zargarian, V. Haddadi-Asl, N. Ahmadbeigi, S. Soudi, Y. Gheisari, A. Hajarizadeh, and Y. Mohammadi, “In vitro differentiation of human cord blood-derived unrestricted somatic stem cells into hepatocyte-like cells on poly(epsilon-caprolactone) nanofiber scaffolds.,” Cells Tissues Organs, vol. 190, no. 3, pp. 135–149, Jan. 2009.

[30]       A. Tabar, M. Hassan, Z. M. Hassan, S. Mohammad, A. Mostafaie, S. Shahabi, M. Ebtekar, and S. Mahmoud, “Naloxone can improve the anti-tumor immunity by reducing the CD4 + CD25 + Foxp3 + regulatory T cells in BALB / c mice,” Int. Immunopharmacol., vol. 9, no. 12, pp. 1381–1386, 2009.

[31]       H. Baharvand, S. M. Hashemi, and M. Shahsavani, “Differentiation of human embryonic stem cells into functional hepatocyte-like cells in a serum-free adherent culture condition.,” Differentiation., vol. 76, no. 5, pp. 465–77, May 2008.

[32]       S. M. Hashemi, M. Sc, S. Soudi, a Ghaemi, H. Soleimanjahi, and D. Ph, “Study the Effect of Echinacea Purpurea Extract on Cellular Delayed Type Hypersensitivity and Splenocyte Proliferation in BALB / c Mice,” Cell J., vol. 9, no. 4, pp. 254–261, 2008.

[33]       S. M. Hashemi, Z. M. Hassan, S. Soudi, and S. Shahabi, “The effect of vaccination with the lysate of heat-shocked tumor cells on nitric oxide production in BALB/c mice with fibrosarcoma tumor.,” Cell Biol. Int., vol. 32, no. 7, pp. 835–40, Jul. 2008.

[34]       S. M. H. Sara Soudi, Ahmad Z. Hosseini, Sima Rafati, Reza H.Fesharki , Kasra Esmaeilnia, “Comparison the effect of intranasal with subcutaneous BCG immunization on nitric oxide production in macrophages and parasite burden in BALB/c mice infected with Leishmania major,” Daneshvar Med., 2008.

[35]       S. M. Hashemi, Z. M. Hassan, S. Soudi, T. Ghazanfari, M. Kheirandish, and S. Shahabi, “Evaluation of anti-tumor effects of tumor cell lysate enriched by HSP-70 against fibrosarcoma tumor in BALB/c mice.,” Int. Immunopharmacol., vol. 7, no. 7, pp. 920–927, 2007.

[36]       B. H. Mohamadnejad M, Namiri M, Bagheri M, Hashemi SM, Ghanaati H, Zare Mehrjardi N, Kazemi Ashtiani S, Malekzadeh R, M. Mohamadnejad, M. Namiri, M. Bagheri, S. M. Hashemi, H. Ghanaati, N. Zare Mehrjardi, S. Kazemi Ashtiani, R. Malekzadeh, and H. Baharvand, “Phase 1 human trial of autologous bone marrow-hematopoietic stem cell transplantation in patients with decompensated cirrhosis,” World J. Gastroenterol., vol. 13, no. 24, pp. 3359–63, Jun. 2007.

[37]       S. M. H. Sara Soudi, Ahmad Z. Hosseini, Sima Rafati, Reza H.Fesharaki, Kasra Esmaeilnia, “Comparison the Protective Effect of Mucosal BCG Vaccination with Subcutaneous Against Leishmania Major Infection in Susceptible BALB/c Mice,” Cell J., vol. 3, no. 32, pp. 238–245, 2007.

[38]       S. Soudi, A. Z. Hosseini, S. Rafati, R. Fesharki, K. Esmaeilnia, and S. M. Hashemi, “Comparison the Effect of the Rectal and Subcutaneous BCG Immunization on Nitric Oxide Production in Peritoneal Macrophages of BALB/c Mice Infected with Leishmania Major,” Kowsar Med. J., 2007.

[39]       S. Soudi, S. Mahmoud, A. Zavaran, and A. Ghaemi, “Antileishmanial Effect of Echinacea purpurea Root Extract Cultivated in Iran,” Iran. J. Pharm. Res., vol. 6, no. November 2005, pp. 147–149, 2007.

[40]       H. Baharvand, S. M. Hashemi, S. Kazemi Ashtiani, and A. Farrokhi, “Differentiation of human embryonic stem cells into hepatocytes in 2D and 3D culture systems in vitro.,” Int. J. Dev. Biol., vol. 50, no. 7, pp. 645–52, Jan. 2006.

[41]       K. A. M. HASHEMI S.M., ZAHIR MOHAMMAD HASSAN, SOOUDI S., GHAZANFARI T., SHAHABI S., “The Effect of Injection of Heat Shocked Tumor Cell Lysate on Splenocytes Proliferation and Nitric Oxide Production in BALB/c Mice with Fibrosarcoma Tumor,” Cell J., vol. 8, pp. 106–113, 2006.

[42]       S. Shahabi, M. Hashemi, Z. M. Hassan, M. Javan, S. Z. Bathaie, T. Toraihi, Z. Zakeri, B. Ilkhanizadeh, and N. H. Jazani, “The effect of post-burn local hyperthermia on the reducing burn injury: the possible role of opioids.,” Int. J. Hyperth. Off. J. Eur. Soc. Hyperthermic Oncol. North Am. Hyperth. Gr., vol. 22, no. 5, pp. 421–431, 2006.

[43]       T. T. Shahabi Sh, Mohammad Hassan Z, Hashemi SM, Shahrokhi S, Karimi Pour M, Kazem Nejad A, Bathaei SZ, “Hyperthermia Can Accelerate the Healing Process of 2nd Degree Burn Wounds,” J. Kerman Univ. Med. Sci., 2005.

[44]       S. Noori, G.-A. Naderi, Z. M. Hassan, Z. Habibi, S. Z. Bathaie, and S. M. M. Hashemi, “Immunosuppressive activity of a molecule isolated from Artemisia annua on DTH responses compared with cyclosporin A.,” Int. Immunopharmacol., vol. 4, no. 10–11, pp. 1301–6, Oct. 2004.

 Journal Editorial board memberships:

1.     Deputy editor of “Research In Medicine”

2.     Member of Editorial Board of “International Journal of Health Studies”

3.       Member of Editorial Board of Journal of Stem Cell and Regenerative Biology

4.       Member of Editorial Board of “International Journal of Hematology and Therapy”